Gastrointestinal Mucosal Blood Flow

Dietary nitrate increases gastric mucosal blood flow and mucosal defense.

Salivary nitrate from dietary or endogenous sources is reduced to nitrite by oral bacteria. In the acidic stomach, nitrite is further reduced to bioactive nitrogen oxides, including nitric oxide (NO). In this study, we investigated the gastroprotective role of nitrate intake and of luminally applied nitrite against provocation with diclofenac and taurocholate. Mucosal permeability ((51)Cr-EDTA ...

Gastrointestinal blood flow in the dog.

• Measurement of blood flow to the individual gastrointestinal organs has been hampered by limitations of methodology. The oldest and most direct experimental technique for estimating blood flow to an organ is timed collection of its total venous outflow. Traumatic surgical procedures are required to accomplish such collections from the stomach, intestine, or colon. This method is not applicabl...

Monitoring Gastrointestinal Mucosal Perfusion

Timing of postexercise carbohydrate-protein supplementation: roles of gastrointestinal blood flow and mucosal cell damage on gastric emptying in humans.

It is well known that protein ingestion immediately after exercise greatly stimulates muscle protein synthesis during the postexercise recovery phase. However, immediately after strenuous exercise, the gastrointestinal (GI) mucosa is frequently injured by hypoperfusion in the organ/tissue, possibly resulting in impaired GI function (e.g., gastric emptying; GE). The aim of this study was to exam...

Effect of sucralfate on gastric mucosal blood flow in rats.

Sucralfate possesses site protective and cytoprotective actions and heals ulcers effectively, but its effect on gastric mucosal blood flow is unknown. Using an ex vivo gastric chamber preparation, we studied the effect of sucralfate on gastric mucosal blood flow in rats by laser doppler flowmetry. Under both fasting and fed states, measurements of gastric mucosal blood flow and damage were made...